Expression of cancer cell-intrinsic PD-1 associates with PD-L1 and p-S6 and predicts a good prognosis in nasopharyngeal carcinoma

Aims: Programmed cell death ligand 1 (PD-L1) is the of programmed (PD-1), which a host immunity inhibitory receptor. Expression PD-L1 in diverse tumor types has been widely discussed, while there little research about intrinsic-PD-1. Phospho-S6 (p-S6) an important downstream effector PI3K/AKT/mTOR pathway. Our study was focused on investigating expression cancer cell-intrinsic PD-1, and p-S6 proteins aimed to illustrate their relationship clinical significances nasopharyngeal carcinoma (NPC). Methods: The tissues NPC, non-cancerous epithelia, primary matching metastatic lesion detected by immunohistochemistry. Results: co-expression PD-1 were significantly higher NPC (all P<0.05). paired increased P<0.01). patients with positive showed overall survival rate (P =0.035). However, lower =0.031, P=0.044, respectively). Interestingly, had (P=0.042). Multivariate Cox proportional hazard regression analysis confirmed that independent prognostic factors for patients. Conclusions: associates proteins, might serve as good biomarker, could be poor biomarker